Epic is planning its first Unreal Engine 3 based title to hit the shelves in the 2006 (ages away i know). Furthermore its first title based on the new dropping engine (see earlier post), will be unrelated to the unreal franchise, and will have a strong single-player focus. They have plans for an Unreal Tournament and an Unreal 3 game both based on the new engine too, but that will come later.

Source: CVG